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KMID : 1146320140020010064
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Journal of Health Technology Assessment
2014 Volume.2 No. 1 p.64 ~ p.67
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Diagnostic Tests for Anaplastic Lymphoma Kinase Gene Rearrangement in Non-Small-Cell Lung Cancer
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Oh Hyun-Joo
Kim Da-Woon
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Abstract
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Accurate determination of anaplastic lymphoma kinase (ALK) rearrangement is important in lung cancer patients, especially in determining their eligibility for crizotinib therapy. Basically immunohistochemistry (IHC) mothod and fluorescence in situ hybridization (FISH) has been used to detect ALK gene rearrangement. IHC mothod has been used for primary test and FISH has been regarded as the gold standard method for detecting ALK rearrangement in determining their eligibility for crizotinib therapy. However FISH requires a fluorescence microscope, and the signals are labile and rapidly fade over time. In this study, we reviewed current diagnostic tests for ALK gene rearrangement in non-small-cell lung cancer in Korea and potentiality of the new improved test for new alternative test to FISH.
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KEYWORD
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Anaplastic lymphoma kinase, ALK, Non small cell lung cancer, NSCLC
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